Preheat the oven to 350°F.
Line a baking sheet with parchment paper and set aside.
In a frying pan over medium heat, add the olive oil, ground beef, salt, onion powder, and 1 tsp. of garlic powder. Cook until browned.
Next, assemble the burger sauce. In a small bowl, combine the mayonnaise, ketchup, mustard, relish, and the other tsp. of garlic powder. Mix until well combined and set aside.
Slice the slider buns in half and place the bottom on the baking sheet.
Evenly spread the burger sauce over the buns.
Once the ground beef is done cooking, add it to the buns evenly.
Top with shredded cheese and put the tops of the buns on.
In a small bowl, mix together the melted butter and oregano. Brush the mixture over the tops of the sliders and sprinkle on the sesame seeds.
Bake in the oven for 10-12 minutes.
Pull apart and enjoy!
